Correlation of comparative genomic hybridization results of 100 archival uveal melanomas with patient survival.

摘要: Comparative genomic hybridization (CGH) was used to elucidate DNA sequence copy number imbalances in 100 archival formalin-fixed, paraffin-embedded (FFPE) uveal melanoma cases. Of these cases, 51 were from patients who survived ≥9 years post diagnosis without evidence of metastasis; the remaining 49 died metastatic disease. Viable probe generated 82 allowing correlation CGH findings with survival for all but 18 Copy revealed by tested univariate prognostic significance. The most powerful predictor a poor prognosis gain 18q11.2, which subsequently compared other significant chromosomal regions, as well histologic and clinical factors, multivariate analysis. There also differential X chromosome involvement correlations between male female may be significance prognosis. This large-scale analysis material is intended direct further gene-specific study malignancy melanoma.