Prevalence of drug resistance and importance of viral load measurements in Honduran HIV-infected patients failing antiretroviral treatment

摘要: Objective The Honduran HIV/AIDS Program began to scale up access HIV therapy in 2002. Up May 2008, more than 6000 patients received combination antiretroviral (cART). As drug resistance is the major obstacle for effective treatment, purpose of this study was assess prevalence HIV-1-infected individuals. Methods We collected samples from 138 individuals (97 adults and 41 children) on cART with virological, immunological or clinical signs treatment failure. HIV-1 pol sequences were obtained using an in-house method. Resistance mutations identified according 2007 International AIDS Society (IAS)-USA list predicted susceptibility scored anrs algorithm. Results Resistance detected 112 (81%), 74% 98% children. Triple-, dual- single-class documented 27%, 43% 11% subjects, respectively. Multiple logistic regression showed that independently associated type failure [virological (odds ratio (OR)=1) vs. (OR=0.11; 95% confidence interval (CI) 0.030–0.43) (OR=0.037; CI 0.0063–0.22)], route transmission (OR=42.8; 3.73–491), years (OR=1.81; 1.11–2.93). Conclusion The high HIV-infected A majority subjects triple-class nucleoside reverse transcriptase inhibitors, nonnucleoside inhibitors protease inhibitors. Virologically defined a strong predictor resistance, indicating viral load testing needed correctly identify attributable resistance.