NK cells, hypoxia and trophoblast cell differentiation
作者： Damayanti Chakraborty , M.A. Karim Rumi , Michael Soares
DOI: 10.4161/CC.20542
关键词: Biology 、 Spiral artery 、 Cell biology 、 Immunology 、 Trophoblast cell 、 Transcription factor 、 Trophoblast 、 Hypoxia (medical) 、 Placenta 、 Fetus 、 Cellular differentiation
摘要: Hemochorial placentation is characterized by extensive remodeling of the maternal vasculature, converting them to flaccid low resistance vessels. This process greatly facilitates exchange nutrients and gases between mother fetus. Two key modulators that orchestrate these vascular changes have been identified at fetal interface, natural killer (NK) cells invasive trophoblast cells. Hypoxia-inducible factor (HIF) transcription factors direct cellular responses oxygen, influencing lineage commitment promoting development lineage. short review focuses on role NK uterine spiral artery subsequent modulation oxygen tensions interface.
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