miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas
作者： Lei Shi , Dongyi Jiang , Guan Sun , Yi Wan , Shuguang Zhang
DOI: 10.1007/S11060-012-0951-Z
关键词: Cell growth 、 microRNA 、 Meningioma 、 Tumor growth 、 Cell cycle checkpoint 、 Retinoblastoma 、 Signal transduction 、 Biology 、 Pathology 、 In vitro 、 Cancer research
摘要: Meningiomas, one of the most common benign brain tumors in humans, arise from arachnoid cells meninges. Our investigations have revealed that miR-335 is a typical microRNA overexpressed meningiomas humans. Characterization effects overexpression demonstrated elevated levels increased cell growth and inhibited cycle arrest G0/G1 phase vitro; addition, reduction had opposite effect on tumor progression. Further, previous studies shown mechanism proliferation meningioma associated with alterations expression human retinoblastoma 1 (Rb1). results indicate plays an essential role by directly targeting Rb1 signaling pathway. Thus, our highlight novel molecular interaction between Rb1, may represent potential therapeutic agent to target cells.
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