Phenotypic analysis of airway eosinophils and lymphocytes in a Th-2-driven murine model of pulmonary inflammation.
作者： A D Watkins , C A Hatfield , S F Fidler , G E Winterrowd , J R Brashler
DOI: 10.1165/AJRCMB.15.1.8679219
关键词: Bronchoalveolar lavage 、 Immunology 、 Nippostrongylus brasiliensis 、 Pathology 、 Naive T cell 、 Allergic inflammation 、 Alpha (ethology) 、 Beta (finance) 、 Biology 、 T-cell receptor 、 Phenotype
摘要: In order to investigate whether the pulmonary response helminth antigens mimics that seen in allergic inflammation of airways, we have examined phenotypic characteristics lymphocytes and eosinophils recruited airways following Nippostrongylus brasiliensis (N.b.) infection. Specifically, cellular was divided into an early a late phase. During there small but significant increase neutrophil numbers recovered by bronchoalveolar lavage (BAL). Phenotypic analysis BAL leukocytes revealed rise percentage expressing naive T cell markers CD45RB L-selectin, activation marker IL-2R. addition, during response, increased gamma delta TCR, not alpha beta TCR. contrast, marked much larger accumulation, lungs BAL, memory CD4+ influx small, hypodense wh...
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