The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity

摘要: ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular homeostasis. Here we demonstrate a role of ABCG1 as mediator tumour immunity. Abcg1(-/-) mice have dramatically suppressed subcutaneous MB49-bladder carcinoma B16-melanoma growth prolonged survival. We show that reduced in is myeloid cell intrinsic associated with phenotypic shift the macrophages tumour-promoting M2 to tumour-fighting M1 within tumour. exhibit an bias towards polarization increased NF-κB activation direct cytotoxicity for vitro. Overall, our study demonstrates absence inhibits through modulation macrophage function tumour, illustrates link between homeostasis cancer.