Function of a human cyclin gene as an oncogene.
作者： P. W. Hinds , S. F. Dowdy , E. N. Eaton , A. Arnold , R. A. Weinberg
关键词: Cyclin D 、 Cyclin Gene 、 Retinoblastoma protein 、 Oncogene 、 Cyclin D1 、 Cyclin A2 、 Cyclin A 、 Oncogene Proteins 、 Biology 、 Cancer research
摘要: The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here cultured cells, cDNA clone can contribute to transformation complementing defective adenovirus E1A oncogene. In such this candidate oncogene indeed functions like an oncogene, similar role progression vivo.
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