SNHG20 knockdown suppresses proliferation, migration and invasion, and promotes apoptosis in non-small cell lung cancer through acting as a miR-154 sponge.
作者： Jin Lingling , Jiang Xiangao , He Guiqing , Shi Jichan , Su Feifei
DOI: 10.1016/J.BIOPHA.2019.108648
关键词: Function (biology) 、 Cancer research 、 In vivo 、 Small nucleolar RNA 、 Competing endogenous RNA 、 Apoptosis 、 Lung cancer 、 Gene knockdown 、 Biology 、 RUNX2
摘要: Long noncoding RNAs (LncRNAs) play critical roles in the development and progression of cancers. However, little is known about function mechanism lncRNAs non-small cell lung cancer (NSCLC). In this study, we investigated expression functional role lncRNA small nucleolar RNA host gene 20 (SNHG20) as well its underlying NSCLC. Our results showed that SNHG20 was significantly up-regulated NSCLC tissues cells. High implicated with poor prognosis patients. Moreover, knockdown suppressed proliferation, migration invasion, induced apoptosis Furthermore, could a competing endogenous (ceRNA) to elevate ZEB2 RUNX2 by sponging miR-154. Rescue assays revealed miR-154 inhibition reverse inhibitory effect silence on invasion More importantly, tumor growth vivo through suppressing elevating expression. summary, promotes up-regulating NSCLC, providing promising therapeutic target for
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