Sporadic Amplification of the HER2/neu Protooncogene in Adenocarcinomas of Various Tissues
作者： Y Shiloh , Z Josefberg , M Tal , D Givol , A Deutch
DOI:
关键词: Cancer research 、 Gene 、 Biology 、 Immunoprecipitation 、 DNA 、 Tyrosine kinase 、 HER2/neu 、 Molecular biology 、 Adenocarcinoma 、 Gene duplication 、 Antibody
摘要: The HER2/neu protooncogene was found to be amplified in 6 of 109 primary adenocarcinoma tumors. No amplification 29 other nonadenocarcinomatous In two colon tumors, addition the amplification, DNA rearrangement gene also observed. explored detail one tumor and it shown confined 3' region gene. Moreover, this expressed an aberrant polypeptide with a molecular weight 190,000, which is larger by approximately 5,000 than normal protein. protein immunoprecipitated site-specific antibodies against synthetic peptide from COOH-terminal end protein; displayed intrinsic tyrosine kinase activity leading self-phosphorylation.
aacrjournals.org参考文章(19)
T. A. Libermann, Y. Yarden, H. Soreq, J. Schlessinger, A. D. Bartal, N. Razon, Expression of Epidermal Growth Factor Receptors in Human Brain Tumors Cancer Research. ,vol. 44, pp. 753- 760 ,(1984)
S Fukushige, K Matsubara, M Yoshida, M Sasaki, T Suzuki, K Semba, K Toyoshima, T Yamamoto, Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line Molecular and Cellular Biology. ,vol. 6, pp. 955- 958 ,(1986) , 10.1128/MCB.6.3.955
R. M. Hudziak, J. Schlessinger, A. Ullrich, Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 7159- 7163 ,(1987) , 10.1073/PNAS.84.20.7159
R Dalla-Favera, S Martinotti, R. Gallo, J Erikson, C. Croce, Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas Science. ,vol. 219, pp. 963- 967 ,(1983) , 10.1126/SCIENCE.6401867
P. Di Fiore, J. Pierce, M. Kraus, O Segatto, C. King, S. Aaronson, erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells Science. ,vol. 237, pp. 178- 182 ,(1987) , 10.1126/SCIENCE.2885917
C. King, M. Kraus, S. Aaronson, Amplification of a novel v-erbB-related gene in a human mammary carcinoma Science. ,vol. 229, pp. 974- 976 ,(1985) , 10.1126/SCIENCE.2992089
Jun Yokota, Kumao Toyoshima, Takashi Sugimura, Tadashi Yamamoto, Masaaki Terada, Hector Battifora, MartinJ Cline, Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. The Lancet. ,vol. 327, pp. 765- 767 ,(1986) , 10.1016/S0140-6736(86)91782-4
Cornelia I. Bargmann, Mien-Chie Hung, Robert A. Weinberg, The neu oncogene encodes an epidermal growth factor receptor-related protein Nature. ,vol. 319, pp. 226- 230 ,(1986) , 10.1038/319226A0
K. Semba, N. Kamata, K. Toyoshima, T. Yamamoto, A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 6497- 6501 ,(1985) , 10.1073/PNAS.82.19.6497
R.M. Kris, I. Lax, W. Gullick, M.D. Waterfield, A. Ullrich, M. Fridkin, J. Schlessinger, Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein Cell. ,vol. 40, pp. 619- 625 ,(1985) , 10.1016/0092-8674(85)90210-7