Active Specific Immunotherapy of Malignant Melanoma and Peptide Mimics of the Human High-Molecular-Weight Melanoma-Associated Antigen

摘要: The realization that tumor cells utilize multiple mechanisms to escape from immune recognition and destruction has stimulated interest in developing applying immunotherapeutic strategies which target both humoral cellular immunity malignant cells. As a result, the tumor-associated antigens (TAA) used as targets have be expressed on cell surface membrane of Furthermore, since most TAA for active specific immunotherapy are self-antigens, challenge facing immunologists is develop effective breaking tolerance self-antigens. This chapter describes one strategy relies use peptide mimics human high-molecular-weight melanoma-associated antigen (HMW-MAA) immunogens implement patients with melanoma. These mimics, isolated phage display libraries by panning anti-HMW-MAA monoclonal antibodies, expected induce immunity.