Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-α, angiostatin, or endostatin
作者： Sophie de Boüard , Jean-Sébastien Guillamo , Christo Christov , Nathalie Lefévre , Pierre Brugières
DOI: 10.1089/104303403765701178
关键词: Pathology 、 Endothelial stem cell 、 Endostatin 、 In vivo 、 Interferon 、 Angiostatin 、 Angiogenesis 、 Cancer research 、 In vitro 、 Biology 、 Transfection
摘要: Inhibition of angiogenesis has been considered among the most promising approaches to treat highly vascularized solid tumors such as glioblastoma. In this study, we designed and validated a new in vitro assay system based on implantation tumor cells into organotypic brain slice cultures. We evaluated effects local production three endogenous inhibitors angiogenesis, angiostatin, endostatin, interferon (IFN)-α1, using stably transfected rat (9L) human (GL15) glioblastoma vascularization growth. Despite similar effectiveness proteins classic endothelial cell migration assay, IFN-α1 demonstrated potent antiangiogenic effect vivo, after intracerebral genetically modified cells, caused dramatic decrease volume revealed by magnetic resonance imaging postmortem histology. The mechanisms antitumor were likely cause...
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