Racial differences in selected cytokine allelic and genotypic frequencies among healthy, pregnant women in North Carolina

摘要: Background: Genetic susceptibility to diseases is likely influenced by common DNA variants in the form of single nucleotide polymorphisms (SNPs). The value SNPs for linkage and association mapping studies may depend on distribution SNP allele frequencies across populations. Objectives: To establish allelic among Caucasian African American women tumor necrosis factor (TNF)α, transforming growth (TGF)β1, interleukin-10 (IL10), interleukin-6 (IL6), interferon (IFN)γ. Materials methods: was extracted from whole blood 123 healthy, pregnant women. PCR-based genotyping performed genes encoding TNFα (−308G/A), TGFβ1 (codon 10C/T, codon 25C/G), IL10 (−1082A/G, −819T/C, −592A/C), IL6 (−174C/G) IFNγ (874T/A). Allele were determined Hardy–Weinberg Equilibrium Linkage Disequilibrium tests. Differences between Caucasians Americans assessed χ2 Amitage trend test. Results: genotypic IFNγ, but not TNFα, TGFβ1, IL10, differed significantly women. Conclusions: Recognition racial differences selected cytokines important designing powering future investigating role human disease.