Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake
作者： Chiara Lanzani , Guido Gatti , Lorena Citterio , Elisabetta Messaggio , Simona Delli Carpini
DOI: 10.1161/HYPERTENSIONAHA.115.06415
关键词: Essential hypertension 、 Na+/K+-ATPase 、 Salt intake 、 Biology 、 Hormone 、 Endocrinology 、 Blood pressure 、 Lanosterol synthase 、 Internal medicine 、 Ouabain 、 Low sodium
摘要: Circulating levels of endogenous ouabain (EO), a vasopressor hormone adrenocortical origin, are increased by sodium depletion. Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has missense polymorphism (rs2254524 V642L) that affects EO biosynthesis cells. Here, we investigated the hypothesis synthase rs2254524 alleles vivo impact blood pressure (BP) and responses evoked low dietary Na intake (<100 mEq/d, 2 weeks) among patients with mild essential hypertension. During salt diet, declines both systolic BP (SBP: -8.7±1.7 versus -3.0±1.5; P=0.013) diastolic (DBP: -5.1±0.98 -1.4±0.94 mm Hg; P<0.05), slope long-term pressure-natriuresis relationship affected significantly presence A variant (AA: 0.71±0.22, AC 0.09±0.13, CC 0.04±0.11 mEq/mm Hg/24 h; P=0.028). In addition, rose ≈25% response to diet this was associated circulating EO. Lanosterol gene polymorphisms influence sensitivity changes diet. The is markedly heterogeneous. Approximately 25% experienced adverse effects, is, when reduced may be at risk. augmented further supports view function abnormal some hypertensives.
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