Heat-shock proteins can promote as well as regulate autoimmunity.

摘要: Heat-shock proteins (Hsps) are among the most highly conserved and immunogenic shared by microbial agents mammals. Under physiological conditions, ubiquitously distributed Hsps maintain integrity function of other cellular when cells exposed to stressful stimuli. However, owing their nature stress inducibility, may become targets immune response. The T and/or antibodies induced a Hsp crossreact with corresponding mammalian (molecular mimicry) trigger an autoimmune response, which if unchecked can lead pathology clinical manifestations. Furthermore, enhanced expression under unveil previously hidden antigenic determinants that initiate perpetuate reactivity. Also, innate mechanisms activated reinforce even direct type adaptive response protein. have been implicated in induction propagation autoimmunity several diseases, including rheumatoid arthritis, atherosclerosis 1 diabetes. possess immunoregulatory attributes as well therefore, being exploited for immunomodulation various immune-mediated disorders.