作者: Robert L. Keith
DOI: 10.1513/PATS.201107-038MS
关键词: Oncology 、 Cancer 、 Lung cancer 、 Dysplasia 、 Clinical trial 、 Internal medicine 、 Metaplasia 、 Breast cancer 、 Medicine 、 Carcinogenesis 、 Disease
摘要: Lung cancer is the leading cause of death in United States, and majority diagnoses are made former smokers. Although avoidance tobacco abuse smoking cessation clearly will have greatest impact on lung development, effective chemoprevention could prove to be more than treatment established, advanced-stage disease. Chemoprevention use dietary or pharmaceutical agents reverse block carcinogenic process has been successfully applied common malignancies other (including recent reports prevention breast high-risk individuals). Despite previous studies failing identify agents, our ability define highest-risk populations understanding tumor premalignant biology continue make advances. Squamous cell carcinogenesis bronchial epithelium starts with normal progresses through hyperplasia, metaplasia, dysplasia, c...