Combinations of an erk inhibitor and a cdk4/6 inhibitor and related methods

作者: Ellen H. Filvaroff , Ida Aronchik , Gordon L. Bray , Carmen Maria Barnes

DOI:

关键词: DiseasePharmacologyMAPK/ERK pathwayMedicine

摘要: The present invention provides methods of treating, stabilizing or lessening the severity progression a disease disorder associated with one both ERK1 and ERK2.

参考文章(13)
Jeffery L. Kutok, Howard M. Stern, Treatment of cancers using pi3 kinase isoform modulators ,(2013)
Igor Mochalkin, Brian L. Hodous, Theresa L. Johnson, Nadia Brugger, Ngan Nguyen, Donald Bankston, Reinaldo Jones, Andreas Goutopoulos, Lesley Liu-Bujalski, Hui Qiu, Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity ,(2012)
Richland Wayne Tester, Shomir Ghosh, Arthur F. Kluge, Juswinder Singh, Russell C. Petter, Heteroaryl compounds and uses thereof ,(2010)
David C. Dalgarno, William C. Shakespeare, Xiaotian Zhu, Wei-Sheng Huang, Yihan Wang, Compounds for inhibiting cell proliferation in egfr-driven cancers ,(2012)
Jonas Grina, Rustam Ferdinand Garrey, Aihe Zhou, Huifen Chen, Kirk Robarge, Mark Joseph Chicarelli, Li Ren, David A. Moreno, James F. Blake, Peter J. Mohr, Jacob Schwarz, John Gaudino, Serine/threonine kinase inhibitors ,(2014)
Annette O. Walter, Robert Tjin Tham Sjin, Henry J. Haringsma, Kadoaki Ohashi, Jing Sun, Kwangho Lee, Aleksandr Dubrovskiy, Matthew Labenski, Zhendong Zhu, Zhigang Wang, Michael Sheets, Thia St Martin, Russell Karp, Dan van Kalken, Prasoon Chaturvedi, Deqiang Niu, Mariana Nacht, Russell C. Petter, William Westlin, Kevin Lin, Sarah Jaw-Tsai, Mitch Raponi, Terry Van Dyke, Jeff Etter, Zoe Weaver, William Pao, Juswinder Singh, Andrew D. Simmons, Thomas C. Harding, Andrew Allen, Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC Cancer Discovery. ,vol. 3, pp. 1404- 1415 ,(2013) , 10.1158/2159-8290.CD-13-0314
Qingsong Liu, Yogesh Sabnis, Zheng Zhao, Tinghu Zhang, Sara J. Buhrlage, Lyn H. Jones, Nathanael S. Gray, Developing Irreversible Inhibitors of the Protein Kinase Cysteinome Chemistry & Biology. ,vol. 20, pp. 146- 159 ,(2013) , 10.1016/J.CHEMBIOL.2012.12.006
Raul Rabadan, Brunangelo Falini, Enrico Tiacci, Hairy cell leukemia biomarkers and methods of using same ,(2012)