ASPIRIN DOSE AND DURATION OF USE AND RISK OF COLORECTAL CANCER IN MEN

摘要: Background & Aims: Long-term data on the risk of colorectal cancer according to dose, duration, and consistency aspirin therapy are limited. Methods: We conducted a prospective study 47,363 male health professionals who were ages 40–75 years at enrollment in 1986. Biennially, we collected use, other factors, diagnoses cancer. confirmed all reports through 2004 by review medical records. Results: During 18 follow-up, documented 975 cases over 761,757 person-years. After adjustment for men regularly used (≥2 times per week) had multivariate relative (RR) 0.79 (95% confidence interval, [CI], 0.69–0.90) compared with nonregular users. However, significant reduction required least 6–10 use ( P trend=.008) was no longer evident within 4 discontinuing (multivariate RR, 1.00; CI, 0.72–1.39). The benefit appeared related increasing cumulative average dose: denied any RRs 0.94 (CI, 0.75–1.18) 0.5–1.5 standard tablets week, 0.80 0.63–1.01) 2–5 0.72 0.56–0.92) 6–14 0.30 0.11–0.81) >14 week trend=.004). Conclusions: Regular, long-term reduces among men. necessitates 6 consistent maximal doses greater than 14 week. potential hazards associated such should be carefully considered.