Diastereoselective control through hydrogen bonding in the aziridination of the chiral allylic alcohols by acetoxyaminoquinazolinone.
作者： Murat Cakici , Semistan Karabuga , Hamdullah Kilic , Sabri Ulukanli , Ertan Şahin
DOI: 10.1021/JO902092S
关键词: Allylic rearrangement 、 Chemistry 、 Quinazolinone 、 Selectivity 、 Carbonyl group 、 Ketone 、 Allylic alcohol 、 Alcohol 、 Organic chemistry 、 Hydrogen bond
摘要: A high diastereoselectivity (up to >99:1) is found for the aziridinations of chiral allylic alcohols with acetoxyaminoquinazolinone (Q-NHOAc). The selectivity explained in terms hydrogen bonding between hydroxy functionality alcohol and remote carbonyl group quinazolinone.
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