Studies of the Hormonal Control of Postnatal Testicular Descent in the Rat

摘要: Abstract Dihydrotestosterone is believed to control the transinguinal phase of testicular descent based on hormonal manipulation studies performed in postnatal rats. In present study, these experiments were repeated, and results compared with those obtained using antiandrogens flutamide cyproterone acetate. 17β-estradiol completely blocked descent, but testosterone dihydrotestosterone equally effective reversing this inhibition. Neither nor acetate prevented rats despite marked peripheral antiandrogenic action. Further analysis data revealed a correlation between size descent. Androgen receptor blockade did not produce reduction consequently prevent whereas estradiol alone caused atrophy maldescent. Reduction dosage or concomitant administration androgens human chorionic gonadotropin resulted both increased degree These suggest that growth neonatal rat testis may contribute its passage into scrotum.