Emerging role of lipids of Candida albicans, a pathogenic dimorphic yeast

摘要: It is clear that C. albicans lipids have gained tremendous importance in recent years. In addition to being a barrier for entrance of various metabolites, it also provides the site action synthesis enzyme(s) involved cell wall morphogenesis and antifungal action. While alterations lipid composition during yeast mycelia transition been observed, most studies, fluctuations reported could due environmental factors induction [4,5]. A understanding biosynthesis metabolic blocks likely shed further light on selective interactions antifungals. Despite multifacet role functions this pathogenic yeast, their exact involvement poorly understood. The situation little better with regard ergosterol its metabolism. Ergosterol is, indeed, important anti-candidal activity appears be albicans. fluctuation phospholipid led altered properties plasma membrane namely, fluidity, transport activities drug sensitivity, which suggest that-a critical level individual proper functioning membrane. What far from clear. Many unanswered questions relating PI sphingomyelin signal transduction, phospholipases maintenance composition, transfer proteins assembly asymmetry are some aspects merit work.