Identification and Analysis of Multiple Glycine Transport Systems in Isolated Mammalian Renal Tubules
作者： R E Hillman , I Albrecht , L E Rosenberg
DOI: 10.1016/S0021-9258(18)91905-8
关键词: Alanine 、 Ouabain 、 Microbial collagenase 、 Proline 、 Glycine transport 、 Glycine 、 Sodium 、 Paper chromatography 、 Biochemistry 、 Chemistry
摘要: Abstract Rabbit renal tubule segments, prepared by collagenase digestion, were used to study glycine transport. A distinct two-limbed curve found when studying the effects of substrate concentration on transport indicated presence at least two systems for glycine. These could not be distinguished their response metabolic inhibitors or removal sodium from incubation medium. Proline and alanine both inhibited competitively, but shown share different with The use proline maximal inhibitory concentrations allowed separation into three kinetically systems. kinetic constants derived this analysis examined aid a computer program computed values agree experimental determinations.
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