Synthesis and Characterization of Arsenolipids: Naturally Occurring Arsenic Compounds in Fish and Algae

摘要: Arsenic-containing lipids (arsenolipids) are natural products present in fish and algae. Because these compounds occur foods, there is considerable interest their human toxicology. We report the synthesis characterization of seven arsenic-containing lipids, including six products. The comprise dimethylarsinyl groups attached to saturated long-chain hydrocarbons (three compounds), fatty acids (two monounsaturated long chain compounds). arsenic group was introduced through sodium dimethylarsenide or bis(dimethylarsenic) oxide. latter route provided higher more reproducible yields, consequently, this pathway followed synthesize compounds. Mass spectral properties described assist identification samples. pure synthesized arsenolipids will be used for vitro experiments with cells test uptake, biotransformation, possible toxic effects.