Microsatellite instability as a prognostic factor in resected colorectal cancer liver metastases.
作者： Riad Haddad , Robert T. Ogilvie , Marina Croitoru , Victoria Muniz , Robert Gryfe
关键词: Survival analysis 、 Prognostic factor 、 Medicine 、 Oncology 、 Colorectal cancer 、 Cohort study 、 Pathogenesis 、 Surgical oncology 、 Chromosome instability 、 Microsatellite instability 、 Internal medicine
摘要: Background: Two distinct genetic mutational pathways characterized by either chromosomal instability or high-frequency microsatellite (MSI-H) are currently recognized in the pathogenesis of colorectal cancer (CRC). Recently, it has been shown that patients with primary CRC displays MSI-H have a significant, stage-independent, multivariate survival advantage. Untreated hepatic metastases incurable and associated median 4 to 12 months. Conversely, surgical resection selected results 20% 50% cure rate. The aim this study was investigate prognostic importance undergoing metastases.
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Mark Redston, Carcinogenesis in the GI tract: from morphology to genetics and back again. Modern Pathology. ,vol. 14, pp. 236- 245 ,(2001) , 10.1038/MODPATHOL.3880292
Xiao‐Ping Zhou, Jean‐Marc Hoang, You‐Jun Li, Raquel Seruca, Fatima Carneiro, Manuel Sobrinho‐Simoes, Ragnhild A Lothe, Catherine M Gleeson, SE Hilary Russell, Françoise Muzeau, Jean‐François Fléjou, Khê Hoang‐Xuan, Rosette Lidereau, Gilles Thomas, Richard Hamelin, None, Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites Genes, Chromosomes and Cancer. ,vol. 21, pp. 101- 107 ,(1998) , 10.1002/(SICI)1098-2264(199802)21:2<101::AID-GCC4>3.0.CO;2-4
Robert Gryfe, Hyeja Kim, Eugene T.K. Hsieh, Melyssa D. Aronson, Eric J. Holowaty, Shelley B. Bull, Mark Redston, Steven Gallinger, Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer New England Journal of Medicine. ,vol. 342, pp. 69- 77 ,(2000) , 10.1056/NEJM200001133420201
Julie M. Cunningham, Cheong-Yong Kim, Eric R. Christensen, David J. Tester, Yann Parc, Lawrence J. Burgart, Kevin C. Halling, Shannon K. McDonnell, Daniel J. Schaid, Catherine Walsh Vockley, Vickie Kubly, Heidi Nelson, Virginia V. Michels, Stephen N. Thibodeau, The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. American Journal of Human Genetics. ,vol. 69, pp. 780- 790 ,(2001) , 10.1086/323658
Christophe Rosty, Maurice Chazal, Marie-Christine Etienne, Christian Letoublon, Andr� Bourgeon, Jean-Robert Delpero, Denis Pezet, Philippe Beaune, Pierre Laurent-Puig, G�rard Milano, Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival. International Journal of Cancer. ,vol. 95, pp. 162- 167 ,(2001) , 10.1002/1097-0215(20010520)95:3<162::AID-IJC1028>3.0.CO;2-J
D. SCOTT LIND, GEORGE A. PARKER, J. SHELTON HORSLEY, MICHAEL J. KORNSTEIN, JAMES P. NEIFELD, HARRY D. BEAR, WALTER LAWRENCE, Formal hepatic resection of colorectal liver metastases. Ploidy and prognosis. Annals of Surgery. ,vol. 215, pp. 677- 684 ,(1992) , 10.1097/00000658-199206000-00015
Anne Schneider, Serge Rohr, Michael D. Kelly, Ragai Mitry, Massimo Pignatelli, Caroline J. Doré, Marie-Pierre Gaub, Daniel Jaeck, Christian Meyer, Pierre Oudet, Nagy A. Habib, Microsatellite instability and allelic imbalance in primary and secondary colorectal cancer. Australian and New Zealand Journal of Surgery. ,vol. 70, pp. 587- 592 ,(2000) , 10.1046/J.1440-1622.2000.01904.X
Victoria A. Marcus, Lisa Madlensky, Robert Gryfe, Hyeja Kim, Kelvin So, Anna Millar, Larissa K.F. Temple, Eugene Hsieh, Tad Hiruki, Steven Narod, Bharati V. Bapat, Steven Gallinger, Mark Redston, Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. The American Journal of Surgical Pathology. ,vol. 23, pp. 1248- 1255 ,(1999) , 10.1097/00000478-199910000-00010
Yuman Fong, Joseph Fortner, Ruth L. Sun, Murray F. Brennan, Leslie H. Blumgart, Clinical Score for Predicting Recurrence After Hepatic Resection for Metastatic Colorectal Cancer: Analysis of 1001 Consecutive Cases Annals of Surgery. ,vol. 230, pp. 309- 321 ,(1999) , 10.1097/00000658-199909000-00004
Philip J. Crowe, Jia-Lin Yang, Christophe R. Berney, Catherine Erskine, John M. Ham, Richard Fisher, Pamella J. Russell, Genetic Markers of Survival and Liver Recurrence after Resection of Liver Metastases from Colorectal Cancer World Journal of Surgery. ,vol. 25, pp. 996- 1001 ,(2001) , 10.1007/S00268-001-0069-5