Contributions of capillary electrophoresis to neuroscience.

作者: Theodore Lapainis , Jonathan V. Sweedler

DOI: 10.1016/J.CHROMA.2007.10.098

关键词:

摘要: Capillary electrophoresis (CE) is a small-volume separation approach amenable to the analysis of complex samples for their small molecule, peptide and protein content. A number features CE make it method choice addressing questions related neurochemistry. The figures merit inherent that well suited studying cell-to-cell intracellular signaling include sample volumes, high efficiency, ability online analyte concentration, compatibility with sensitive high-information content detection methods. variety instrumental aspects are detailed, including methods sampling techniques particularly useful molecules. Studies have used these increase our understanding neurobiology emphasized throughout. One notable application single neuron chemical analysis, research area has been greatly advanced by CE.

参考文章(149)
Ryan D. Johnson, Marian Navratil, Bobby G. Poe, Guohua Xiong, Karen J. Olson, Hossein Ahmadzadeh, Dmitry Andreyev, Ciarán F. Duffy, Edgar A. Arriaga, Analysis of mitochondria isolated from single cells. Analytical and Bioanalytical Chemistry. ,vol. 387, pp. 107- 118 ,(2006) , 10.1007/S00216-006-0689-6
Jason S. Page, Stanislav S. Rubakhin, Jonathan V. Sweedler, Single-neuron analysis using CE combined with MALDI MS and radionuclide detection. Analytical Chemistry. ,vol. 74, pp. 497- 503 ,(2002) , 10.1021/AC0156621
Hiroyuki Nishi, Tsukasa Fukuyama, Shigeru Terabe, Chiral separation by cyclodextrin-modified micellar electrokinetic chromatography Journal of Chromatography A. ,vol. 553, pp. 503- 516 ,(1991) , 10.1016/S0021-9673(01)88522-8
Koji Otsuka, Shigeru Terabe, Enantiomeric separation by micellar electrokinetic chromatography Trends in Analytical Chemistry. ,vol. 12, pp. 125- 130 ,(1993) , 10.1016/0165-9936(93)87013-N
Dean S. Burgi, Ring Ling. Chien, Optimization in sample stacking for high-performance capillary electrophoresis Analytical Chemistry. ,vol. 63, pp. 2042- 2047 ,(1991) , 10.1021/AC00018A028
Nilhan Gunasekera, Karen J. Olson, Karin Musier-Forsyth, Edgar A. Arriaga, Capillary Electrophoretic Separation of Nuclei Released from Single Cells Analytical Chemistry. ,vol. 76, pp. 655- 662 ,(2004) , 10.1021/AC034916A
Luis Hernandez, Jose Escalona, Phillipe Verdeguer, Norberto A. Guzman, In Vivo Monitoring of Brain Glutamate by Microdialysis Coupled to Capillary Electrophoresis and Laser Induced Fluorescence Detection Journal of Liquid Chromatography. ,vol. 16, pp. 2149- 2160 ,(1993) , 10.1080/10826079308019921