Rotavirus VP6 preparations as a non-replicating vaccine candidates
作者： Somayeh Jalilvand , Sayed Mahdi Marashi , Zabihollah Shoja
DOI: 10.1016/J.VACCINE.2015.05.026
关键词:
摘要: Rotavirus (RV) structural proteins VP4 and VP7, located on the surface of viral particles, elicit neutralizing antibodies (Abs) are therefore considered to be important components RV vaccines. However, despite inducing Abs, limits cross-neutralizing activity lack full correlation with protection limit usefulness these as protective agents against disease. VP6 protein, which forms middle layer is discussed an alternative vaccine candidate since it can induce cross-protective immune responses different strains although Ab raised not neutralizing. This report reviews functions that lead considering
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