Self-assembled nanospheres with multiple endohedral binding sites pre-organize catalysts and substrates for highly efficient reactions

摘要: Tuning reagent and catalyst concentrations is crucial in the development of efficient catalytic transformations. In enzyme-catalysed reactions substrate bound-often by multiple non-covalent interactions-in a well-defined pocket close to active site enzyme; this pre-organization facilitates highly Here we report an artificial system that co-encapsulates catalysts substrates within confined space defined M12L24 nanosphere contains 24 endohedral guanidinium-binding sites. Cooperative binding means sulfonate guests are bound much more strongly than carboxylates. This difference has been used fix gold-based firmly, with remaining sites left pre-organize substrates. strategy was applied Au(I)-catalysed cyclization acetylenic acid enol lactone which resulted higher reaction rates. We also found encapsulated sulfonate-containing Au(I) did not convert neutral (acid) substrates, so could have potential substrate-selective catalysis base-triggered on/off switching catalysis.