Value of hepatocellular phase imaging after intravenous gadoxetate disodium for assessing hepatic metastases from gastroenteropancreatic neuroendocrine tumors: comparison with other MRI pulse sequences and with extracellular agent.

摘要: To compare hepatocellular phase imaging after intravenous gadoxetate disodium with other MRI pulse sequences and extracellular agent for assessing hepatic metastases from gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). In this IRB-approved, HIPAA-compliant retrospective study, we included 30 patients (15 women, mean age: 58 years, range 44–77 years) GEP-NEN metastatic to the liver, who underwent disodium. Six were reviewed by two radiologists score tumor–liver interface (TLI) on a 5-point scale, assess lesion detectability in different liver segments (divided into 3 zones/patient), measure size. Contrast-to-noise ratio (CNR) was calculated each sequence. 19 patients, size CNR dynamic gadopentetate dimeglumine compared phase. Wilcoxon signed-rank test used TLI scores, size, median CNR, using Bonferroni correction multiple testing. Interobserver agreement analyzed Krippendorff's alpha, concordance correlation coefficient (CCC) relative difference. Hepatocellular had best (mean reader 1 = 1.2, 2 = 1.3) all (p < 0.0001) excellent interobserver (Krippendorff's alpha = 1.0), maximum (61/90 zones), highest measurement (CCC 0.9875 smallest difference − 1.567%), (31.2, p < 0.008). also when imaging. offers significant advantages assessment of metastasis GEP-NEN, should be routinely considered follow-up these patients.