Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS.
作者： E. Gelmann , M Popovic , D Blayney , H Masur , G Sidhu
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摘要: The acquired immune deficiency syndrome (AIDS) is characterized by T-lymphocyte dysfunction and frequently accompanied opportunistic infections Kaposi's sarcoma. Human T-cell leukemia virus (HTLV) associated with malignancies can transform T lymphocytes in vitro. In an attempt to find evidence of HTLV infection patients AIDS, DNA from samples peripheral blood 33 AIDS was analyzed Southern blot-hybridization a radiolabeled cloned probe. Analysis both the fresh (uncultured) cells cultured growth factor revealed presence integrated proviral sequences two patients, whom had antibody HTLV. could not be detected obtained these individuals at later date, consistent possibility that population infected become depleted.
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