The Idea and Evidence for the Tumor Stemness Switch
作者： Bikul Das , Rika Tsuchida , Sylvain Baruchel , David Malkin , Herman Yeger
DOI: 10.1007/978-1-60327-227-8_35
关键词:
摘要: The maintenance of stemness normal stem cell is a complex process, where transcription factors like Oct-4, Bmi-1, and signaling pathways such as Wnt/β-catenin play important roles. This molecular set mechanisms not only expands the population (self-renewal) but also keeps cells in state “de-differentiation.” Thus, differentiation are mutually exclusive tightly regulated, idea variation over time has been incorporated. However, unlike stemness, tumor may be complexity microenvironment, especially hypoxic stress allow for stemness.
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sci-hub.st 参考文章(102)
S. Sell, H. A. Dunsford, Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. American Journal of Pathology. ,vol. 134, pp. 1347- 1363 ,(1989)
J. E. Till, T. W. Mak, G. B. Price, J. S. Senn, E. A. McCulloch, Cellular subclasses in human leukemic hemopoiesis. Hamatologie und Bluttransfusion. ,vol. 19, pp. 33- 45 ,(1976) , 10.1007/978-3-642-87524-3_4
Ralph E. Durand, Intermittent blood flow in solid tumours--an under-appreciated source of 'drug resistance'. Cancer and Metastasis Reviews. ,vol. 20, pp. 57- 61 ,(2001) , 10.1023/A:1013181107707
Thomas Brabletz, Andreas Jung, Simone Spaderna, Falk Hlubek, Thomas Kirchner, Migrating cancer stem cells — an integrated concept of malignant tumour progression Nature Reviews Cancer. ,vol. 5, pp. 744- 749 ,(2005) , 10.1038/NRC1694
Adrian L. Harris, Hypoxia — a key regulatory factor in tumour growth Nature Reviews Cancer. ,vol. 2, pp. 38- 47 ,(2002) , 10.1038/NRC704
Suling Liu, Gabriela Dontu, Max S Wicha, Mammary stem cells, self-renewal pathways, and carcinogenesis Breast Cancer Research. ,vol. 7, pp. 86- 95 ,(2005) , 10.1186/BCR1021
Peter C. Nowell, Mechanisms of Tumor Progression Cancer Research. ,vol. 46, pp. 2203- 2207 ,(1986)
Gloria H. Heppner, Fred R. Miller, The cellular basis of tumor progression. International Review of Cytology-a Survey of Cell Biology. ,vol. 177, pp. 1- 56 ,(1997) , 10.1016/S0074-7696(08)62230-5
George Klein, Foulds' dangerous idea revisited: the multistep development of tumors 40 years later. Advances in Cancer Research. ,vol. 72, pp. 1- 23 ,(1998) , 10.1016/S0065-230X(08)60698-3
Yong-Guang Jiang, Yong Luo, Da-lin He, Xiang Li, Lin-lin Zhang, Tao Peng, Ming-Chuan Li, Yun-Hua Lin, Role of Wnt/β‐catenin signaling pathway in epithelial‐mesenchymal transition of human prostate cancer induced by hypoxia‐inducible factor‐1α International Journal of Urology. ,vol. 14, pp. 1034- 1039 ,(2007) , 10.1111/J.1442-2042.2007.01866.X