Microsatellite instability and mismatch repair target gene mutations in cell lines and xenografts of prostate cancer.
作者： Xiaodong Sun , Ceshi Chen , Robert L. Vessella , Jin-Tang Dong
DOI: 10.1002/PROS.20390
关键词:
摘要: BACKGROUND Mismatch repair (MMR) and microsatellite instability (MSI) occur in prostate cancer, but their role has not been well documented. METHODS In 6 cell lines 22 xenografts from PCR gel electrophoresis were performed to detect MSI by analyzing markers BAT-25 BAT-26 frameshift mutations mononucleotide repeats BAX, IGF2R, MSH3, MSH6, TGFBR2. RESULTS Four of (67%) 3 (14%) showed MSI. At least 1 mutation was detected the same 4 5 (23%) xenografts. While MSH3 frequently mutated lines, BAX TGFBR2 frequent alterations both xenografts. CONCLUSIONS MSI related MMR deficiency is relatively high-grade tumors, target genes involved death proliferation appeared be selected for during prostatic carcinogenesis. Prostate 66:660–666, 2006. © 2005 Wiley-Liss, Inc.
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