Microsatellite instability in adenocarcinoma of the prostate

摘要: Abstract Instability of dinucleotide tandem repeat sequences has been reported to play a major role in the carcinogenic pathway familial colon cancer, as well potential carcinogenesis other sporadic neoplasms. To determine frequency short instability adenocarcinoma prostate, we studied 40 tumors that were stratified according tumor grade. The tissue samples screened with di-, tri- and tetranucleotide markers spanning wide range chromosomal loci, including an androgen receptor gene trinucleotide repeat. Microsatellite was observed overall only one (2.5%) prostate adenocarcinomas studied. This replication error-positive demonstrated length alterations at two loci. Five showed alteration microsatellite size single locus. These not considered have phenotype. All changes identified either within or (4 20 total analyzed). Both expansions contractions identified. case also included separate metastatic nodal tissue. Additional analysis revealed allelic patterns identical normal control. Our data indicate is rare adenocarcinoma. Therefore, observation this low error suggests most carcinomas develop absence widespread accumulation somatic mutations sequences. Additionally, these genetic appear occur more often