Chemotaxis and IL-8 receptor expression in B cells from normal and HIV-infected subjects.

摘要: To date, the activities of alpha chemokines for human peripheral B cells from normal subjects (N-B cells) or HIV-infected (HIV-B are not well established. No report on IL-8R expression N-B and HIV-B has been seen. We in this work that IL-8 growth-regulatory oncogene-alpha (GRO-alpha) induce a chemotactic migration via stimulating IL-8RB these cells. The chemotaxis can be inhibited by IFN-gamma IL-2, augmented IL-4 IL-13, whereas TNF-alpha IL-10 have no influence. TNF-alpha, IL-4, IL-10, IL-13 expressed more abundantly freshly isolated than (51% 15%, respectively). down-regulated IFN-gamma, (selectively IL-8RA), up-regulated Importantly, cell toward GRO-alpha blocked anti-IL-8RB polyclonal Ab, but anti-IL-8RA Ab. Our results demonstrate important inflammatory mediators stimulate directional recruitment lymphocytes. migratory behavior some reactions to Th1- Th2-like cytokines modified significantly during HIV infection.