Cockroach allergens and asthma.

摘要: Asthma and allergy are the most common diseases associated with cockroach infestation of houses in United States other parts world. Sensitization exposure to allergens is increased asthma morbidity States, especially among lower socioeconomic groups, including African American Hispanic populations. Exposure first 3 months life has been repeated wheezing asthma. The principal domestic species Blattella germanica Periplaneta americana. Both produce several potent allergens, Bla g 2 (inactive aspartic proteinase), 4 (calycin), 5 (glutathione-S-transferase), group 1 cross-reactive Per a 1, tropomyosin. Structural homology between tropomyosins from cockroaches, mites, shrimp may explain clinical cases oral syndrome. 3-dimensional structures known, biologically active recombinant have produced high-level expression vectors. use should allow mechanisms cockroach-induced be investigated lead development new approaches treatment. Environmental allergen measurements allowed levels that cause allergic sensitization established. Abatement studies shown sustained decrease difficult but can accomplished by professional application insecticides, together rigorous household cleaning. Cockroach an important public health problem affects patients who least likely compliant treatment medications or environmental control. Patient education, improvements housing stock, immunologic strategies successful reduce prevalence