Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

摘要: The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival human tumorigenesis, including gastric cancer. PIK3CA mutations amplification are two major causes of overactivation this cancers. However, until work, there was no sound investigation on the association with clinical outcome cancer, particularly latter. Using direct sequencing real-time quantitative PCR, we examined amplification, their clinicopathological characteristics cancer patients. PIK3CA were found 8/113 (7.1%) 88/131 (67%) patients, respectively. closely associated increased phosphorylated Akt (p-Akt) level. No relationship between significantly positively cancer-related death. Importantly, Kaplan-Meier curves revealed that patients had shorter times than without amplification. Our data showed not common, but its very common may be mechanism activating PI3K/Akt poor Collectively, signaling an effective therapeutic target