The JAK/STAT signaling cascade in gastric carcinoma (Review).

摘要: Gastric carcinoma remains one of the most prevalent forms cancer worldwide, despite decline in incidence rates, increased awareness disease and advancement treatment strategies. Helicobacter pylori infection, dietary factors, lifestyle influences various genetic aberrations have been shown to contribute development progression gastric cancer. Recent studies on genomic landscape adenocarcinoma identified several key signaling molecules, including epidermal growth factor receptor family (ErbB) members, vascular endothelial (VEGFR) members PI3K/Akt/mTOR pathway components, that implicated molecular pathogenesis cancers. However, clinical trials with compounds target these molecules failed show a significant improvement overall survival rates when supplemented conventional therapies. Therefore, it is essential identify effective prognostic and/or diagnostic biomarkers develop targeted The JAK/STAT cascade principal signal transduction cytokine signaling, regulating cellular processes such as cell proliferation, differentiation, migration survival. Numerous vivo vitro dysregulated driving force solid cancers well hematopoietic malignancies. Hence, large number preclinical drugs targeting this are currently underway. Notably, aberrant has also In review, we focus ongoing research discuss therapeutic potential for