Cordycepin induces apoptosis in SGC-7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS
作者： Moussa Ide Nasser , Muqaddas Masood , Wei Wei , Xiaochun Li , Yifa Zhou
关键词:
摘要: Medicinal plants are affluent sources of several effectual natural drugs. Among them cordycepin which is extracted from Cordyceps militaris a hopeful chemotherapy agent due to its extensive anti-inflammatory, anti-proliferative, antioxidant, and antitumor characteristics. This study investigated the efficacy in context human gastric cancer SGC‑7901 searched for cell death procedure. Cordycepin incorporates mitochondrial-mediated apoptosis cells with help regulating mitochondrial extrinsic pathways by inhibition A3AR drive activation DR3, promote PI3K/Akt protein expression as well collapse membrane potential (MMP). In addition, phosphorylation DNA damage induced production reactive oxygen species (ROS), mediates cycle cessation at S phase. Collectively, this suggests that might be effective modern drug cancer.
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