Inflammation in COPD: implications for management.

摘要: Chronic obstructive pulmonary disease (COPD) is recognized by the Global Initiative for Obstructive Lung Disease guidelines as an inflammatory state, and treatment rationales are provided accordingly. However, not all physicians follow or even aware of these guidelines. Research has shown that COPD inflammation involves multiple cells mediators underlying pathology differs from asthma inflammation. For reasons, therapeutic agents effective in patients may be optimal patients. exacerbations intensified events compared with stable COPD. The clinical systemic consequences believed to result chronic observed suggest intensity a key factor exacerbation severity frequency. Although inhaled corticosteroids commonly used essential management, their efficacy limited, only modest effect at reducing exacerbations. importance needs better understood clinicians, differences versus should considered carefully optimize use anti-inflammatory agents.