Comparative evaluation of rate of hydration and matrix erosion of HEC and HPC and study of drug release from their matrices.

摘要: Abstract Hydrophilic polymers, in contact with the dissolution medium, may swell and make a continuous gel layer, erode or undergo combination of two. The swelling action these polymers is controlled by rate their hydration medium. extent polymer swelling, relative mobilities medium drug, matrix erosion dictate kinetics as well mechanism drug release from polymeric matrices. objective present investigations was to study two hydrophilic, non-ionic cellulose ethers, i.e., hydroxyethylcellulose (HEC) hydroxypropylcellulose (HPC), compare Chlorpheniramine maleate used model drug. Matrix tablets containing chlorpheniramine maleate, HEC HPC dicalcium phosphate were compressed at 156 MPa pressure. polymer, matrices vitro studies carried out buffer (pH 7.4). demonstrated that due relatively larger water uptake, degree considerably higher compared Also, exhibited occurred non-Fickian transport, diffusion while primarily through pores channels structure. t50%, time reach 50% release, for 4.8 h 6.5 which indicates level needed case sustain up 12 hydrophilicity HEC.