Haemodynamic, neuroendocrine and metabolic correlates of circulating cytokine concentrations in congestive heart failure

摘要: Objectives Increased activity of pro-inflammatory cytokines in the circulation has been observed many, though not all, patients with congestive heart failure. To identify predictors cytokine activation failure, we assessed relationship peripheral and hepatic venous to central haemodynamics, neuroendocrine status intermediary metabolism moderate or severe failure. Patients methods Concentrations tumour necrosis factor-α, soluble factor-receptor II interleukin 6 were measured from plasma 58 adult cardiac patients, whom 44 had undergoing catheterization, echocardiography assessment selected metabolic characteristics. Results Peripheral was directly related NYHA class (rs=0·46 P >0·001) inversely 6-min walking distance (rs−0·46, >0·001). factor-α (rs=−0·37, >0·01), but like II, unrelated other haemodynamic measurements. correlated (rs=0·66, (rs −0·52, In addition, right atrial pressure (rs0·55, >0·001 pulmonary artery wedge (rs=−0·50, left ventricular ejection fraction (rs=−0·39, >0·01); multivariate analysis, only an independent predictor concentration ( Comparisons between without failure showed significantly higher group; differences less consistent. Conclusions increased are associated symptoms poor exercise capacity, while most important is elevated systemic pressure. Different still unknown mechanisms may be responsible for release