Comparison of Pneumococcal Conjugate Polysaccharide and Free Polysaccharide Vaccines in Elderly Adults: Conjugate Vaccine Elicits Improved Antibacterial Immune Responses and Immunological Memory

摘要: Background. High functional antibody responses, establishment of immunologic memory, and unambiguous efficacy in infants suggest that an initial dose conjugated pneumococcal polysaccharide (PnC) vaccine may be value a comprehensive adult immunization strategy. Methods. We compared the immunogenicity safety 7-valent PnC (7vPnC) with 23valent (PPV) adults 70 years age who had not been previously vaccinated vaccine. One year later, 7vPnC recipients received booster either (the 7vPnC/7vPnC group) or PPV 7vPnC/PPV group), PPV/7vPnC group). Immune responses were for each 7 serotypes common to both vaccines. Results. Antipolysaccharide enzyme-linked immunosorbent assay concentrations opsonophagocytic titers significantly greater than those 6 5 serotypes, respectively ( , respectively). induced P ! .01 .05 similar after first inoculation, administration alone; lower antibacterial by alone, all ). Conclusion. In adults, is likely elicit higher potentially more effective levels antipneumococcal antibodies PPV. contrast PPV, which induction hyporesponsiveness was observed when used as priming dose, elicits immunological state permits subsequent maintain antipolysaccharide levels.