Prevention of surface-to-human transmission of rotaviruses by treatment with disinfectant spray.
作者： R L Ward , D I Bernstein , D R Knowlton , J R Sherwood , E C Young
DOI: 10.1128/JCM.29.9.1991-1996.1991
关键词:
摘要: A model was developed to examine the effects of disinfectants on transmission infectious rotavirus from a dried surface humans. The initial experiments were designed find method preserving infectivity during drying. Culture-adapted human (CJN strain) at room temperature in different organic suspensions, including fecal matter, several laboratory media, and nonfat dry milk (NDM). Recoveries virus then compared. Fecal matter provided little protection this study relative distilled water, but other suspensions quite protective, especially NDM, which consistently allowed recoveries greater than 50%. When 10(3) focus-forming units unpassaged CJN NDM administered subjects who licked material, 100% (8 8) became infected. effect Lysol brand disinfectant spray (LDS) next examined. Although some against inactivation by LDS, spraying under conditions recommended manufacturer caused titer decrease 5 log10. Consumption (10(3) units) sprayed with LDS no infection 14 subjects, whereas 13 consumed unsprayed infected (P less 0.00001). methods could be used test spread inanimate surfaces
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