Association of Calcium and Phosphate Ions with Collagen in the Mineralization of Vertebrate Tissues

摘要: Among the vertebrate species, collagen is most abundant protein and associated with mineralization of their skeleton dentition in all tissues except enamel. In such tissues, bones, calcifying tendon, dentin, cementum are comprised principally type I collagen, which has been proposed as a template for apatite mineral formation. Recent considerations interaction between calcium phosphate ions major constituents have suggested that polypeptide stereochemistry underlies binding these at sites within hole overlap regions leads to nucleation crystals. The concept fundamental understanding both normal abnormal mineralization, it reviewed this article. Given background, avenues additional research studies will also be described. latter include, instance, how events subsequent nucleation, is, crystal growth development, occur whether they, too, directed by stereochemical parameters; can expected spaces molecules; side chains charged amino acid residues actually point toward into provide putative ions; what phenomena may responsible beyond zones extracellular tissue structural units. These questions discussed broader contributions potential mechanisms mineralization.