Anti-tumor effects of cold atmospheric pressure plasma on vestibular schwannoma demonstrate its feasibility as an intra-operative adjuvant treatment

摘要: Vestibular schwannoma (VS), although a benign intracranial tumor, causes morbidities by brainstem compression. Since chemotherapy is not very effective in most Nf2-negative schwannomas, surgical removal or radiation therapy required. However, depending on the size and site of these approaches may cause loss auditory vestibular functions, severely decrease post-surgical wellbeing. Here, we examined feasibility cold atmospheric pressure plasma (CAP) as an intra-operative adjuvant treatment for VS after surgery. Cell death was efficiently induced both human HEI-193 mouse SC4 cell lines upon exposure to CAP seven minutes. Interestingly, apoptosis necroptosis were simultaneously treatment, completely inhibited pan-caspase receptor-interacting serine/threonine-protein kinase 1 (RIK1) inhibitors. Upon exposure, phenotype similarly observed patient-derived primary cells tumor mass. In addition, recurrence SC4-grafted models. Collectively, results strongly suggest that should be developed efficient surgery eliminate possible remnant cells, minimize area brain