The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis
作者： Tae Gyu Oh , Shu-Ching M. Wang , Bipul R. Acharya , Joel M. Goode , J. Dinny Graham
DOI: 10.1016/J.EBIOM.2016.02.028
关键词:
摘要: Abstract We have previously reported that RORγ expression was decreased in ER−ve breast cancer, and increased improves clinical outcomes. However, the underlying dependent mechanisms repress carcinogenesis not been elucidated. Here we report negatively regulates oncogenic TGF-β/EMT mammary stem cell (MaSC) pathways, whereas positively DNA-repair. demonstrate is: (i) basal-like subtype cancers, (ii) inversely correlated with histological grade drivers of cancer cohorts. Furthermore, integration RNA-seq ChIP-chip data reveals many genes involved TGF-β/EMT-signaling, DNA-repair MaSC pathways (including non-coding RNA, LINC00511). In accordance, pharmacological studies an agonist suppresses viability, migration, EMT transition (microsphere outgrowth) mammosphere-growth. contrast, demonstrates inverse induces TGF-β/EMT-signaling. These findings suggest modulation activity may utility cancer.
uq.edu.au
core.ac.uk 参考文章(56)
Ana Maria Gonzalez-Angulo, Flavia Morales-Vasquez, Gabriel N. Hortobagyi, Overview of Resistance to Systemic Therapy in Patients with Breast Cancer Advances in Experimental Medicine and Biology. ,vol. 608, pp. 1- 22 ,(2007) , 10.1007/978-0-387-74039-3_1
Chrystal Paulos, Gary Glick, Tom Aicher, Dick Bousley, Kinga Majchrzak, Yahong Wang, Weiping Zou, Clarke Taylor, Brian Sanchez, Chad Van Huis, Rodney Morgan, Laura Carter, Peter Toogood, Xia Hu, Don Skalitzky, Xikui Liu, Chuck Lesch, Jacques Moisan, Kellie Demock, Novel RORgamma agonists enhance anti-tumor activity of adoptive T cell therapy (TUM2P.1010) Journal of Immunology. ,vol. 194, ,(2015)
Xiaoping Su, Gabriel G Malouf, Yunxin Chen, Jianping Zhang, Hui Yao, Vicente Valero, John N Weinstein, Jean-Philippe Spano, Funda Meric-Bernstam, David Khayat, Francisco J Esteva, None, Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes. Oncotarget. ,vol. 5, pp. 9864- 9876 ,(2014) , 10.18632/ONCOTARGET.2454
L. D. Miller, J. Smeds, J. George, V. B. Vega, L. Vergara, A. Ploner, Y. Pawitan, P. Hall, S. Klaar, E. T. Liu, J. Bergh, An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 13550- 13555 ,(2005) , 10.1073/PNAS.0506230102
Xin Ye, Wai Leong Tam, Tsukasa Shibue, Yasemin Kaygusuz, Ferenc Reinhardt, Elinor Ng Eaton, Robert A. Weinberg, Distinct emt programs control normal mammary stem cells and tumour-initiating cells Nature. ,vol. 525, pp. 256- 260 ,(2015) , 10.1038/NATURE14897
Victoria Pomp, Cornelia Leo, Andrea Mauracher, Dimitri Korol, Wenjun Guo, Zsuzsanna Varga, Differential expression of epithelial–mesenchymal transition and stem cell markers in intrinsic subtypes of breast cancer Breast Cancer Research and Treatment. ,vol. 154, pp. 45- 55 ,(2015) , 10.1007/S10549-015-3598-6
Cory Y McLean, Dave Bristor, Michael Hiller, Shoa L Clarke, Bruce T Schaar, Craig B Lowe, Aaron M Wenger, Gill Bejerano, GREAT improves functional interpretation of cis-regulatory regions Nature Biotechnology. ,vol. 28, pp. 495- 501 ,(2010) , 10.1038/NBT.1630
Tae Gyu Oh, Peter Bailey, Eloise Dray, Aaron G. Smith, Joel Goode, Natalie Eriksson, John W. Funder, Peter J. Fuller, Evan R. Simpson, Wayne D. Tilley, Peter J. Leedman, Christine L. Clarke, Sean Grimmond, Dennis H. Dowhan, George E. O. Muscat, PRMT2 and RORγ Expression Are Associated With Breast Cancer Survival Outcomes Molecular Endocrinology. ,vol. 28, pp. 1166- 1185 ,(2014) , 10.1210/ME.2013-1403
Matilde Todaro, Miriam Gaggianesi, Veronica Catalano, Antonina Benfante, Flora Iovino, Mauro Biffoni, Tiziana Apuzzo, Isabella Sperduti, Silvia Volpe, Gianfranco Cocorullo, Gaspare Gulotta, Francesco Dieli, Ruggero De Maria, Giorgio Stassi, CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis Cell Stem Cell. ,vol. 14, pp. 342- 356 ,(2014) , 10.1016/J.STEM.2014.01.009
Markus Ringnér, Erik Fredlund, Jari Häkkinen, Åke Borg, Johan Staaf, GOBO: Gene Expression-Based Outcome for Breast Cancer Online PLoS ONE. ,vol. 6, pp. e17911- 11 ,(2011) , 10.1371/JOURNAL.PONE.0017911