Recent Advances in Delivery Systems and Therapeutics of Cinnarizine: A Poorly Water Soluble Drug with Absorption Window in Stomach

摘要: Low solubility causing low dissolution in gastrointestinal tract is the major problem for drugs meant systemic action after oral administration, like cinnarizine. Pharmaceutical products of cinnarizine are commercialized globally as immediate release preparations presenting absorption with and erratic bioavailability. Approaches to enhance bioavailability widely cited literature. An attempt has been made review complications clinical therapeutics poorly water soluble drug: The interest writing this paper summarize pharmacokinetic limitations drug special focus on strategies improvise along effectiveness novel dosage forms circumvent obstacle. provides insight approaches overcome by cyclodextrin complexes forms: self-nanoemulsifying systems buoyant microparticulates. Nanoformulations need systematically explored future, their new role prophylaxis migraine attacks children. Clinical reports have affirmed prophylaxis. Research needs be dedicated develop efficacious directly brain.