Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells.
作者： Dina G. Kristensen , Niels E. Skakkebk , Ewa Rajpert-De Meyts , Kristian Almstrup
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摘要: Foetal development of germ cells is a unique biological process orchestrated by cellular specification, migration and niche in concert with extensive epigenetic transcriptional programs. Many these processes take place early foetal life are hence very difficult to study humans. However, the common precursor testicular cancers � carcinoma situ (CIS) cell thought be an arrested cell. Therefore studies CIS may leverage information on human and, particular, when neoplastic transformation initiated. In this review, we will focus current knowledge epigenetics relate it changes occurring developing mice during colonization. We DNA methylation some best studied histone modifications like H3K9me2, H3K27me3 H3K9ac. also show that contain high levels H3K27ac, which known mark active enhancers. Proper reprogramming seems pre-requisite normal propose alterations programs pathogenic event initiation cancer. Even though only sparse available cues cells, indicate developmental patterns differ from findings emphasize need for further
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