Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.

摘要: The B-raf gene is the human homolog of avian c-Rmil proto-oncogene encoding a 94-kDa serine/threonine kinase detected in cells. We have previously shown that this protein contains amino-terminal sequences not found other proteins mil/raf family. These are encoded by three exons genome. report these conserved and they encode an amino acid sequence similar to gene, indicating both mammalian species product B-raf/c-Rmil protein. also identified two loci: B-raf-1, located on chromosome 7q34, which encodes functional B-raf/Rmil product, B-raf-2, inactive processed pseudogene Xq13.