B-raf polynucleotides
作者： Richard Malcolm Marais , Mike Stratton , Richard Wooster , Andy Futreal , Chris Marshall
DOI:
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摘要: The invention relates to mutations in B-Raf gene products. described are identified human tumors of natural origin. These associated with cancerous phenotypes and can be used as a basis for the diagnosis cancer, cells or predisposition cancer subjects, development anti-cancer therapeutics.
google.nl 参考文章(25)
F Apiou, Alain Eychène, B. Dutrillaux, Georges Calothy, Jean-Vianney Barnier, Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene. Oncogene. ,vol. 7, pp. 1657- 1660 ,(1992)
Kolch W, Rapp Ur, Duh Fm, Sithanandam G, Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. Oncogene. ,vol. 5, pp. 1775- 1780 ,(1990)
R.B. Gayle, K Poindexter, D Cosman, S.K. Dower, S Gillis, T Hopp, R Jerzy, S Kronheim, V Lum, A Lewis, Identification of regions in interleukin-1 alpha important for activity. Journal of Biological Chemistry. ,vol. 268, pp. 22105- 22111 ,(1993) , 10.1016/S0021-9258(20)80654-1
Allan Duby, Kenneth A. Jacobs, Anthony Celeste, Using Synthetic Oligonucleotides as Probes Current protocols in molecular biology. ,vol. 2, ,(1988) , 10.1002/0471142727.MB0604S09
S Ikawa, M Fukui, Y Ueyama, N Tamaoki, T Yamamoto, K Toyoshima, B-raf, a new member of the raf family, is activated by DNA rearrangement. Molecular and Cellular Biology. ,vol. 8, pp. 2651- 2654 ,(1988) , 10.1128/MCB.8.6.2651
Alexandre Izamilov, Thomas J. Digby, Method, apparatus and kits for sequencing of nucleic acids using multiple dyes ,(1997)
Melanie C. MacNicol, Angus M. MacNicol, Nerve Growth Factor-stimulated B-Raf Catalytic Activity Is Refractory to Inhibition by cAMP-dependent Protein Kinase Journal of Biological Chemistry. ,vol. 274, pp. 13193- 13197 ,(1999) , 10.1074/JBC.274.19.13193
Carole Peyssonnaux, Alain Eychène, The Raf/MEK/ERK pathway: new concepts of activation Biology of the Cell. ,vol. 93, pp. 53- 62 ,(2001) , 10.1016/S0248-4900(01)01125-X
K. Huebner, A. ar-Rushdi, C. A. Griffin, M. Isobe, C. Kozak, B. S. Emanuel, L. Nagarajan, J. L. Cleveland, T. I. Bonner, M. D. Goldsborough, Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 3934- 3938 ,(1986) , 10.1073/PNAS.83.11.3934
Melanie C. MacNicol, Anthony J. Muslin, Angus M. MacNicol, Disruption of the 14-3-3 Binding Site within the B-Raf Kinase Domain Uncouples Catalytic Activity from PC12 Cell Differentiation Journal of Biological Chemistry. ,vol. 275, pp. 3803- 3809 ,(2000) , 10.1074/JBC.275.6.3803