Decrease in Measles Virus-Specific CD4 T Cell Memory in Vaccinated Subjects
作者： Denise Naniche , Michel Garenne , Chris Rae , Marianne Manchester , Richard Buchta
DOI: 10.1086/424571
关键词:
摘要: Since the licensure and generalization of an effective measles virus (MV) vaccine 41 years ago, antibody levels have been used as correlates immunity. The long-lived MV-specific response has studied intensely, but dynamics T cell immunity over time not well characterized. We thus characterized profiles MV vaccine-induced antigen-specific cells since vaccination. In a cross-sectional study healthy subjects with history vaccination, we found that CD4 CD8 could be detected up to 34 after IgG remained stable, whereas level decreased significantly in who had vaccinated >21 earlier. These results show vaccination is long lasting reveal different between
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