Immunologic significance of HLA class I genes in measles virus-specific IFN-γ and IL-4 cytokine immune responses
作者： Inna G. Ovsyannikova , Jenna E. Ryan , Robert A. Vierkant , V. Shane Pankratz , Robert M. Jacobson
DOI: 10.1007/S00251-005-0061-6
关键词:
摘要: The variability of immune responses modulated by human leukocyte antigen (HLA) genes and secreted cytokines is a significant factor in the development protective effect measles vaccine. We studied association between type 1 helper T cells (Th1)- Th2-like cytokine HLA class I alleles among 339 schoolchildren who previously received two doses Median values for measles-specific interferon gamma (IFN-γ) interleukin-4 (IL-4) were 40.7 pg/ml [interquartile range (IQR) 8.1–176.7] 9.7 (IQR 2.8–24.3), respectively. Class HLA-A (*0101 *3101) HLA-Cw (*0303 *0501) significantly associated with measles-virus-induced IFN-γ secretion. HLA-A*3101 Cw*0303 higher median response, while A*0101 Cw*0501 lower response. found limited associations gene polymorphisms after vaccination, indicating that molecules may have on measles-vaccine-induced IL-4 Understanding genetic factors influence variations secretion following vaccination will provide insight into both cell-mediated humoral immunity to measles.
springer.com
elsevier.com
sci-hub.se 参考文章(45)
Tom H.M. Ottenhoff, Dienne G. Elferink, Jo Hermans, RenéR.P. de Vries, HLA class II restriction repertoire of antigen-specific T cells. I. The main restriction determinants for antigen presentation are associated with HLA-D/DR and not with DP and DQ Human Immunology. ,vol. 13, pp. 105- 116 ,(1985) , 10.1016/0198-8859(85)90017-5
K Pauksen, J Sjölin, A Linde, G Alm, B Andersson, G Lönnerholm, P Ljungman, Th1 and Th2 cytokine responses after measles antigen stimulation in vitro in bone marrow transplant patients: response to measles vaccination Bone Marrow Transplantation. ,vol. 20, pp. 317- 323 ,(1997) , 10.1038/SJ.BMT.1700903
R. C. Howe, N. Dhiman, I. G. Ovsyannikova, G. A. Poland, Induction of CD4 T cell proliferation and in vitro Th1-like cytokine responses to measles virus. Clinical and Experimental Immunology. ,vol. 140, pp. 333- 342 ,(2005) , 10.1111/J.1365-2249.2005.02766.X
F. T. Cutts, L. E. Markowitz, Successes And Failures In Measles Control The Journal of Infectious Diseases. ,vol. 170, ,(1994) , 10.1093/INFDIS/170.SUPPLEMENT_1.S32
Gregory A. Poland, Robert M. Jacobson, The genetic basis for variation in antibody response to vaccines Current Opinion in Pediatrics. ,vol. 10, pp. 208- 215 ,(1998) , 10.1097/00008480-199804000-00017
Inna G. Ovsyannikova, Robert M. Jacobson, Robert A. Vierkant, Steven J. Jacobsen, V. Shane Pankratz, Gregory A. Poland, The contribution of HLA class I antigens in immune status following two doses of rubella vaccination. Human Immunology. ,vol. 65, pp. 1506- 1515 ,(2004) , 10.1016/J.HUMIMM.2004.07.001
Nancy J Cox, Prevention and control of influenza The Lancet. ,vol. 354, ,(1999) , 10.1016/S0140-6736(99)90373-2
Gregory A Poland, Robert M Jacobson, Daniel Schaid, S Breanndan Moore, Steven J Jacobsen, The association between HLA class I alleles and measles vaccine-induced antibody response: evidence of a significant association. Vaccine. ,vol. 16, pp. 1869- 1871 ,(1998) , 10.1016/S0264-410X(98)00017-6
Edgar Schmitt, Petra Hoehn, Christoph Huels, Sigrid Goedert, Norbert Palm, Erwin Rüde, Tieno Germann, T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β European Journal of Immunology. ,vol. 24, pp. 793- 798 ,(1994) , 10.1002/EJI.1830240403
Rosa Maria Wong-Chew, Judy A. Beeler, Susette Audet, José Ignacio Santos, Cellular and humoral immune responses to measles in immune adults re-immunized with measles vaccine. Journal of Medical Virology. ,vol. 70, pp. 276- 280 ,(2003) , 10.1002/JMV.10390